HCID 86679587, compound → HCID 71542648, compound

Participants

Reaction Steps

4-((S)-2-((R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide (2.9 g, 4.34 mmol) was dissolved in HCl 4M in EtOAc (15 ml). The reaction was stirred at RT for 30 minutes. A precipitate formed, and it was filtered and dried in the vacuum oven to give 4-((S)-2-((R)-2-amino-3-phenylpropanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide as an hydrochloride salt. (2 g, 3.52 mmol, 81% yield).

Provenance & Evidence