Ammonium formate → HCID 89455849, compound

Participants

Reaction Steps

To a mixture of 1-(benzyloxy)-2-methyl-1-oxopropan-2-yl 4-(N-(tert-butoxycarbonyl)methylsulfonamido)-3-(cyclopropylmethoxy)benzoate (0.5 g, 0.890 mmol) and 10% Pd/C (0.100 g) in MeOH (30 ml), ammonium formate (0.337 g, 5.34 mmol) was added, and the mixture was heated to reflux for 1 hour. After cooling the catalyst was filtered off and the solvent was evaporated; the residue was dissolved in ethyl acetate and washed with 0.5N HCl and brine. The organic phase was dried over Na2SO4, filtered and evaporated to give 2-(4-(N-(tert-butoxycarbonyl)-methylsulfonamido)-3-(cyclopropylmethoxy)benzoyloxy)-2-methylpropanoic acid as a white powder (0.402 g, 0.853 mmol, 96% yield, MS/ESI+ 493.9 [MNa]+).

Provenance & Evidence