HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-hydroxyacetoxy)ethyl)pyridine 1-oxide → (S)-4-(2-(2-(2-(N-(tert-butoxycarbonyl)methylsulfonamido)-isonicotinoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-hydroxyacetoxy)ethyl)pyridine 1-oxide | HCID 86679512 | — |
| Reactant | 2-(N-(tert-butoxycarbonyl)methylsulfonamido)isonicotinic acid | HCID 89460059 | — |
| Product | (S)-4-(2-(2-(2-(N-(tert-butoxycarbonyl)methylsulfonamido)-isonicotinoyloxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide | HCID 131734759 | — |
Reaction Steps
This Step was performed as Step 10, Scheme 21, starting with 2-(N-(tert-butoxycarbonyl)methylsulfonamido)isonicotinic acid and (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-hydroxyacetoxy)ethyl)pyridine 1-oxide (See Scheme 21, step 6-9)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09265768B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-cc01c46a1cae46ba9504350bf704d58a |
| Source note | uspto-grants-2016_02 |