2-Thiophenecarboxylic acid → HCID 86679604, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of thiophene-2-carboxylic acid (500 mg, 3.90 mmol) in acetone (20 ml), K2CO3 (593 mg, 4.29 mmol) was added, and mixture was stirred for 5 minutes, then KI (64.8 mg, 0.390 mmol) was added, followed by dropwise addition of tert-butyl 2-bromoacetate (0.634 ml, 4.29 mmol). The mixture was heated at 50° C. overnight. The solid residue was filtered out and washed with DCM; the solvent was evaporated and 2-tert-butoxy-2-oxoethyl thiophene-2-carboxylate was obtained as a clear oil (945 mg, 3.90 mmol, 100% yield, MS/ESI+ 264.9 [MNa]+) and used in the following reaction without further purification.

Provenance & Evidence