HCID 90414341, compound → HCID 80692262, compound

HRID 1776715Notes

Reaction equation

HRID 1776715 reaction equation
[C:1]([CH2:4][C:5]1([C:12]([OH:14])=[O:13])[CH2:9][CH2:8][C:7]([CH3:11])([CH3:10])[CH2:6]1)([OH:3])=O>C(OC(=O)C)(=O)C>[CH3:11][C:7]1([CH3:10])[CH2:8][CH2:9][C:5]2([C:12](=[O:13])[O:14][C:1](=[O:3])[CH2:4]2)[CH2:6]1

Participants

3

Reactant 1

HCID 90414341HCID 90414341, compound

Product 1

HCID 80692262HCID 80692262, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

To a round bottomed flask equipped with a stir bar and reflux condenser, were added 1-(carboxymethyl)-3,3-dimethylcyclopentanecarboxylic acid (1.1 g, 5.5 mmol) and acetic anhydride (20 mL). The reaction mixture was refluxed for 3 h, cooled to RT, and concentrated to dryness to afford the title compound as a colorless solid. 1H NMR (300 MHz, DMSO-d6) δ 2.89 (s, 2H), 2.43-2.24 (m, 1H), 2.20-2.15 (m, 2H), 1.87-1.49 (m, 6H).

Workup

  1. customTo a round bottomed flask equipped with a stir bar
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was refluxed for 3 h
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-a22b09cefd1e4ad8aaadc49c6cb7de27
Source dataset
uspto-grants-2016_02
Patent number
US09265770B2

Reaction notes

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