HCID 71295625, compound → HCID 136341365, compound

Participants

Reaction Steps

To a degassed solution of 5-(5-(benzyloxy)-6-(4-fluoro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (150 mg, 0.22 mmol) was dissolved in THF (5 mL) and charged with 10% palladium on carbon (0.1 g). The mixture was hydrogenated at room temperature under hydrogen pressure for 4 hours. The reaction mixture was filtered and the filtrate was extract with EtOAc and washed with H2O, brine, dried over Na2SO4. After concentrated, the resulting residue was purified using prep-TLC to provide 5-(6-(4-fluoro-1H-pyrrolo[2,3-c]pyridin-2-yl)-5-hydroxypyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (120 mg, yield: 92%). 1H-NMR (CDCl3, 400 MHz) δ 12.00 (s, 1H), 11.17 (s, 1H), 8.67 (s, 1H), 8.52 (s, 1H), 8.01 (t, J=6.0 Hz, 3H), 7.91 (s, 1H), 7.52 (s, 2H), 7.41˜7.35 (m, 3H), 3.19 (s, 3H), 2.95 (s, 3H), 2.80 (d, J=4.0 Hz, 3H). MS (M+H)+: 604.

Provenance & Evidence