Potassium Phosphate, Tribasic → HCID 71295546, compound

Participants

Reaction Conditions

Reaction Steps

To a degassed solution of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (110 mg, 0.22 mmol), 2,12-dichloro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indole (64 mg, 0.22 mmol) and K3PO4 (176 mg, 0.66 mmol) in dioxane/H2O (0.8 mL/0.2 mL) was added Pd2(dba)3 (10 mg, 0.01 mmol) and X-Phos (10 mg, 0.02 mmol) under N2. The mixture was heated to 80° C. and then stirred for 1 hour. The reaction mixture was cooled to RT, diluted with EtOAc and filtered. The filtrate was washed with H2O, brine, dried over Na2SO4. After concentrated, the resulting residue was purified using prep-TLC (petroleum ether:EtOAc=1:1) to provide the desired product of compound 55 (60 mg, yield: 43.2%). 1H-NMR (CDCl3, 400 MHz) δ 8.13 (s, 1H), 7.94˜7.98 (m, 2H), 7.65 (d, J=8.0 Hz, 1H), 7.58 (s, 1H), 7.53 (d, J=8.4 Hz, 1H), 7.42 (d, J=8.4 Hz, 1H), 7.28˜7.31 (m, 2H), 7.11˜7.20 (m, 3H), 5.85˜5.95 (br s, 3H), 3.32 (s, 3H), 2.96 (d, J=4.8 Hz, 3H), 2.72 (s, 3H). MS (M+H)+: 631.

Provenance & Evidence