Potassium Phosphate, Tribasic → HCID 86728247, compound

Participants

Reaction Conditions

Reaction Steps

To a degassed solution of methyl 2-chloro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indole-11-carboxylate (40 mg, 0.13 mmol) and 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (50 mg, 0.10 mmol) in 1,4-dioxane (3 mL), Pd2(dba)3 (10 mg), X-Phos (10 mg) and K3PO4 (60 mg, 0.23 mmol) were added under N2. The mixture was heated to 100° C. for 2 hours. The reaction mixture was cooled to RT, filtered and washed with EtOAc. The filtrate was washed with H2O, brine, dried over Na2SO4. After concentrated, the resulting residue was purified using column chromatography (dichloromethane:MeOH=100:1) to provide the product of methyl 2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indole-11-carboxylate (55 mg, yield: 84%). MS (M+H)+: 655.

Provenance & Evidence