反应详情

温度

60 °C

A mixture of compound 4,7-dibromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one (330 mg, 1.031 mmol) and pyridin-2-amine (97 mg, 1.031 mmol) was stirred at 60° C. for 3 hours. The mixture was then purified using chromatography (petroleum ether:ethyl acetate=3:1) to provide 2-bromo-6,7-dihydrobenzo[2′,3′]oxepino[4′,3′:4,5]imidazo[1,2-a]pyridine (40 mg, yield: 12.3%). 1H-NMR (CDCl3, 400 MHz) δ 8.54 (d, J=2.8 Hz, 1H), 7.78 (d, J=6.8 Hz, 1H), 7.58 (d, J=9.2 Hz, 1H), 7.14˜7.24 (m, 2H), 6.78˜6.88 (m, 2H), 4.42 (d, J=5.2 Hz, 2H), 3.21 (d, J=5.2 Hz, 2H). MS (M+H)+: 315/317.

1. customThe mixture was then purified