HCID 89434881, compound → HCID 89434974, compound

Participants

Reaction Steps

A solution of 5-(11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)methylsulfonamido)benzofuran-3-carboxamide (0.12 g, 0.15 mmol) and NaIO4 (0.16 g, 0.74 mmol) in THF/H2O (12 mL/4 mL) was stirred at room temperature for 24 hours. The mixture was filtered and extracted by EtOAc. The combined organic phases was washed with brine, dried over Na2SO4 and concentrated in vacuo. The resulting residue was purified using prep-HPLC to provide Compound 205. 1H-NMR (Methanol-d4, 400 MHz) δ 8.00 (s, 2H), 7.77˜7.79 (m, 2H), 7.53˜7.66 (m, 1H), 7.51˜7.52 (m, 1H), 7.22˜7.44 (m, 6H), 7.11˜7.14 (m, 1H), 6.99˜7.01 (m, 1H), 6.91˜6.93 (m, 1H), 6.82˜6.86 (m, 1H), 6.14 (s, 2H), 4.84˜4.86 (m, 1H), 4.50˜4.58 (m, 1H), 3.17˜3.20 (m, 3H), 2.93 (s, 3H). MS (M+H)+: 735.

Provenance & Evidence