Acetyl chloride → HCID 86728309, compound

Participants

Reaction Steps

To a solution of 5-(11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (500 mg, 0.81 mmol) in dichloromethane (2 ml) was added acetyl chloride (174 μl, 2.44 mmol) and ((1-methoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane (495 μl, 2.44 mmol). The resulting mixture was stirred at room temperature overnight. Concentrated in vacuo and added Et3N (5 ml). Silica gel chromatography (eluted with 0-5% MeOH/dichloromethane) to provide N-acetyl-5-(11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (500 mg, yield: 94%) MS (M+H)+: 657.

Provenance & Evidence