HCID 90017253, compound → HCID 90013266, compound

Participants

Reaction Steps

7-Nitro-1-(4-trifluoromethylbenzenesulfonyl)-1,2,3,4-tetrahydronaphthalene (0.314 g, 0.816 mmol) was dissolved in ethanol (20 mL) and 10% Pd/C (50 mg) was added. Then, the reaction mixture was agitated under a hydrogen atmosphere (60 p.s.i.) for one hour using a Parr shaker. Next, the reaction mixture was filtered through Celite and concentrated to give 8-(4-trifluoromethylbenzenesulfonyl)-5,6,7,8-tetrahydronaphthalen-2-ylamine. Yield 0.30 g crude. LCMS (ESI): calc. C17H16F3NO2S=355; obs. M+H=356.

Provenance & Evidence