Pyridine → HCID 131730604, compound

HRID 1776982Notes

Reaction equation

HRID 1776982 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:26]([F:29])([F:28])[F:27])[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH2:21])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=3)[CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.ClC1C=C[C:34]([C:35](Cl)=[O:36])=CN=1.[N:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1.C(Cl)[Cl:47]>>[Cl:47][C:45]1[N:40]=[CH:41][C:42]([CH2:34][C:35]([NH:21][CH2:20][C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][C:9]([C:4]4[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=4)([C:26]([F:29])([F:28])[F:27])[CH2:10]3)=[CH:15][C:16]=2[C:22]([F:23])([F:24])[F:25])=[O:36])=[CH:43][CH:44]=1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27821656-Chloronicotinoyl ChlorideHCID 59453382HCID 59453382, compound

Product 1

HCID 131730604HCID 131730604, compound

Procedure

1-{4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoro-methyl)phenyl}methanamine (0.1 g) and 6-chloronicotinic acid chloride (0.04 g) were dissolved in methylene chloride (5 mL), and then pyridine (0.03 g) was added thereto. The resulting mixture was stirred at room temperature for one hour. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (0.1 g).

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. customthe residue was then purified by a column chromatography

Sources & evidence

ORD record
ord-cdda3001a2a642a19cc653b0f7bc4cf3
Source dataset
uspto-grants-2016_02
Patent number
US09266830B2

Reaction notes

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