Sodium Hydroxide → HCID 136348378, compound

HRID 1777070Notes

Reaction equation

HRID 1777070 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6](/[CH:8]=[C:9](\[CH3:12])/[CH:10]=O)[CH:7]=1.CC1C=CC(S([NH:24][NH2:25])(=O)=O)=CC=1.[OH-].[Na+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]([C:8]2[NH:25][N:24]=[CH:10][C:9]=2[CH3:12])[CH:7]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 15303P-ToluenesulfonylhydrazideHCID 54267581613317-59-1

Product 1

HCID 136348378HCID 136348378, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A mixture of (E)-3-(5-chloro-2-hydroxyphenyl)-2-methylacrylaldehyde (40 mg, 0.203 mmol) and 4-methylbenzenesulfonohydrazide (41.7 mg, 0.224 mmol) in Acetonitrile (3 mL) were stirred at room temperature for 3 h and then acetonitrile (2 mL), Sodiumhydroxide (8.95 mg, 0.224 mmol) were added and the mixture was heated at reflux for 16 h. Product was used for further reaction without purification.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 16 h
  3. customProduct was used for further reaction without purification

Sources & evidence

ORD record
ord-94fefff8e6d94e7b84db7fab53e76c59
Source dataset
uspto-grants-2016_02
Patent number
US09266838B2

Reaction notes

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