Ethyl bromoacetate → HCID 90241046, compound

Participants

Role	Name	HCID	Charge
Reactant	Ethyl bromoacetate	HCID 7748	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	HCID 10538586	—
Solvent	Acetonitrile	HCID 6342	—
Product	HCID 90241046	HCID 90241046	90%

Reaction Steps

To a solution of tert-butyl 3,4-dihydro-5-hydroxyisoquinoline-2(1H)-carboxylate (750 mg, 3.01 mmol) and K2CO3 (498 mg, 3.61 mmol) in MeCN was added ethyl 2-bromoacetate (603 mg, 3.61 mmol). The mixture was stirred at room temperature overnight, the mixture was then filtered and the filtrate was concentrated under vacuum to give the desired product (900 mg, 90%). LCMS (m/z): 336.2 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09266836B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-11ac80ecd0964da59f8c6cb1b56711af
Source note	uspto-grants-2016_02