Methylhydrazine → N-methyl-2-morpholinoacetohydrazide
Reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.[CH3:12][NH:13][NH2:14]>C(O)C>[CH3:12][N:13]([C:8](=[O:10])[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)[NH2:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 95 °C
Procedure
In a 25 mL, sealed tube, methyl 2-morpholinoacetate (0.5 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Methylhydrazine (0.16 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 48 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude N-methyl-2-morpholinoacetohydrazide (0.27 g) which was used without further purification in the following step.
Workup
- customIn a 25 mL, sealed tube
- concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)
Sources & evidence
- ORD record
- ord-39a9d0cf47a643c6a14400ddef930ab0
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09266843B2
Reaction notes
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