참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | Methyl 1-Methyl-4-piperidinecarboxylate | HCID 3616844 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-methylpiperidine-4-carbohydrazide | HCID 468608 | 72.5% |
반응 단계
In a 25 mL sealed tube, methyl 1-methylpiperidine-4-carboxylate (0.2 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Hydrazine hydrate (0.127 g, 2 eq.) was introduced dropwise at RT and the reaction mixture was heated at 120° C. for 20 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude 1-methylpiperidine-4-carbohydrazide (0.145 g) which was used without further purification in the following step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09266843B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_02 |
|---|
| ORD ID | ord-f580a074ce6e4ac2b2d43013fb0ffadf |
|---|
| 출처 메모 | uspto-grants-2016_02 |
|---|
