HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)formamide → Avadomide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)formamide | HCID 90000864 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | Avadomide | HCID 24967599 | — |
Reaction Steps
In certain embodiments, when the hydrogen donor is formic acid, the transfer hydrogenation further comprises the step of hydrolyzing N-(3-(2,6-dioxopiperidin-3-yl)-2-methyl-4-oxo-3,4-dihydroquinazolin-5-yl)formamide to form 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione as described herein elsewhere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266858B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-d25fb31a0435468797157c2cb6e3280d |
| Source note | uspto-grants-2016_02 |