Hydrochloric Acid → methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride

Participants

Reaction Steps

A solution of 830 mg (2.8 mmol) of methyl (S)-3-tert-butoxycarbonylamino-2-piperidin-1-yl-propanoate in 15 ml of methanol and 3 ml of hydrochloric acid in isopropanol having a concentration of 5-6N is stirred at 40° C. for 18 h. After concentrating under vacuum, the residue is taken up in ethyl acetate, filtered and dried under vacuum. 630 mg (100%) of methyl (S)-3-amino-2-piperidin-1-ylpropanoate dihydrochloride are obtained in the form of a yellow solid.

Provenance & Evidence