Potassium Carbonate → HCID 67056360, compound

Participants

Reaction Conditions

Reaction Steps

270 mg (1.9 mmol) of potassium carbonate then 380 mg (1.9 mmol) of 4-chloromethyl-2-methylquinoline and 15 mg of potassium iodide are added to a solution of 500 mg (1.6 mmol) of methyl (S)-3-(4-hydroxybenzoyl-amino)-2-piperidin-1-ylpropanoate in 15 ml of 2-butanone. The reaction medium is stirred at 80° C. for 18 h. After filtration, the filtrate is concentrated under vacuum. The crude product is purified by chromatography over silica gel eluted with a 50/50 heptane/ethyl acetate mixture. 620 mg (83%) of methyl (S)-3-[4-(2-methylquinolin-4-ylmethoxy)benzoylamino]-2-piperidin-1-ylpropanoate are obtained in the form of a yellow solid.

Provenance & Evidence