2,5-Dibromopyridine → 5-{4-[2-[4-(5-Bromo-pyridin-2-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanyl-ethoxymethyl)-[1,2,5]thiadiazolidin-3-one

HRID 177728Notes

Reaction equation

HRID 177728 reaction equation
[Br:52][c:53]1[n:54][cH:55][c:56]([Br:59])[cH:57][cH:58]1.[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([CH2:36][c:37]3[cH:38][cH:39][c:40]([B:43]4[O:44][C:45]([CH3:46])([CH3:47])[C:48]([CH3:49])([CH3:50])[O:51]4)[cH:41][cH:42]3)[n:12](-[c:14]3[cH:15][cH:16][c:17]([N:20]4[CH2:21][C:22](=[O:35])[N:23]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:33])[CH3:34])[S:24]4(=[O:25])=[O:26])[cH:18][cH:19]3)[cH:13]2)[cH:4][cH:5][c:6]([Cl:8])[cH:7]1>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][c:11]([CH2:36][c:37]3[cH:38][cH:39][c:40](-[c:53]4[n:54][cH:55][c:56]([Br:59])[cH:57][cH:58]4)[cH:41][cH:42]3)[n:12](-[c:14]3[cH:15][cH:16][c:17]([N:20]4[CH2:21][C:22](=[O:35])[N:23]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:33])[CH3:34])[S:24]4(=[O:25])=[O:26])[cH:18][cH:19]3)[cH:13]2)[cH:4][cH:5][c:6]([Cl:8])[cH:7]1

Participants

3

Reactant 2

HCID 693532,5-DibromopyridineHCID 685829925-(4-{4-(2,4-Dichloro-phenyl)-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-imidazol-1-yl}-phenyl)-1,1-dioxo-2-(2-trimethylsilanyl-ethoxymethyl)-[1,2,5]thiadiazolidin-3-one

Product 1

HCID 685839075-{4-[2-[4-(5-Bromo-pyridin-2-yl)-benzyl]-4-(2,4-dichloro-phenyl)-imidazol-1-yl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanyl-ethoxymethyl)-[1,2,5]thiadiazolidin-3-one

Sources & evidence

ORD record
ord-45cbedfe57bc41f385a643b7dc47139b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…