4-Fluorobenzoic Acid → HCID 118020872, compound

HRID 1777388Notes

Reaction equation

HRID 1777388 reaction equation
[OH:1][NH:2][C:3](=[NH:10])[CH2:4][CH:5]([O:8][CH3:9])[O:6][CH3:7].[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](O)=O)=[CH:14][CH:13]=1>>[CH3:7][O:6][CH:5]([O:8][CH3:9])[CH2:4][C:3]1[N:10]=[C:16]([C:15]2[CH:19]=[CH:20][C:12]([F:11])=[CH:13][CH:14]=2)[O:1][N:2]=1

Participants

3

Reactant 2

HCID 99734-Fluorobenzoic AcidHCID 178495319HCID 178495319, compound

Product 1

HCID 118020872HCID 118020872, compound

Procedure

By using N-hydroxy-3,3-dimethoxypropanimidamide obtained in Reference Example 19 (1.0 g, 6.8 mmol) and 4-fluorobenzoic acid (0.99 g, 7.1 mmol) as the raw materials, the same procedure as in Reference Example 20 was carried out to obtain the title compound (1.4 g) (colorless oil).

Sources & evidence

ORD record
ord-ae2720b6b91e4164b3e7dce8f72fa771
Source dataset
uspto-grants-2016_02
Patent number
US09266870B2

Reaction notes

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