5-Fluoro-2-iodobenzoic acid → HCID 118020970, compound

HRID 1777390Notes

Reaction equation

HRID 1777390 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][OH:15])[CH:10]=[N:9]2)=[N:6][CH:7]=1.[F:16][C:17]1[CH:18]=[CH:19][C:20]([I:26])=[C:21]([CH:25]=1)[C:22]([OH:24])=O>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([I:26])=[C:21]([C:22]([N:6]2[CH2:5][CH2:4][CH2:3][O:15][CH:14]2[CH2:13][C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][N:6]=3)[CH:12]=2)=[O:24])[CH:25]=1

Participants

3

Reactant 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 50970819HCID 50970819, compound

Product 1

HCID 118020970HCID 118020970, compound

Procedure

By using 2-[1-(5-fluoropyridin-2-yl)-1H-pyrazol-4-yl]ethanol obtained in Reference Example 22 (0.21 g, 1.0 mmol) and 5-fluoro-2-iodobenzoic acid (0.16 g, 0.60 mmol), the same procedure as in Reference Example 25 was carried out to obtain the title compound (0.15 g) (pale yellow oil).

Sources & evidence

ORD record
ord-bf56d14070e64901afb7af1a0222abac
Source dataset
uspto-grants-2016_02
Patent number
US09266870B2

Reaction notes

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