HCID 57576766, compound → HCID 86713065, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of [1-(5-fluoropyridin-2-yl)-1H-pyrazol-3-yl]methanol obtained in Reference Example 28 (8.0 g, 34.0 mmol) in CHCl3 (100 mL), 85% manganese dioxide (29.6 g, 0.34 mol) was added, and the resulting mixture was stirred for 3 hours at 60° C. The reaction mixture was filtered through Celite®, the solid was washed with CHCl3, and the filtrate was concentrated under reduced pressure. The obtained residue was washed with diethyl ether, and filtered out to obtain the title compound (5.3 g) (light brown solid).

Provenance & Evidence