4-Chlorophenylboronic acid → HCID 13215562, compound

HRID 1777465Notes

Reaction equation

HRID 1777465 reaction equation
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[Cl:7][C:8]1[CH:13]=[CH:12][C:11](B(O)O)=[CH:10][CH:9]=1>>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:2]2[S:3][CH:4]=[CH:5][N:6]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 764302-Bromothiazole

Product 1

HCID 13215562HCID 13215562, compound

Procedure

Using 2-bromothiazole (0.5 g, 3.05 mmol) and (4-chlorophenyl)boronic acid (0.57 g, 3.65 mmol) and following the procedure described in Example 7, Step 1, the title compound was obtained after purification by column chromatography (15% ethyl acetate in hexane) as colorless viscous liquid (0.5 g, 80% yield). 1H NMR (400 MHz, DMSO-d6): δ 7.95 (d, 2H), 7.92 (d, 1H), 7.80 (d, 1H), 7.55 (d, 2H); LC-MS m/z calculated for [M+H]+195.99. found 195.9.

Sources & evidence

ORD record
ord-947bd233431e45a2af207d1fa67bc52a
Source dataset
uspto-grants-2016_02
Patent number
US09266873B2

Reaction notes

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