反应详情

A mixture of methyl 3-(bromomethyl)benzoate (1.50 g; 6.35 mmol), phenylboronic acid (0.790 g; 6.35 mmol), sodium carbonate (1.35 g; 12.70 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.074 g; 0.063 mmol) in water (4 mL) and dimethoxyethane (12 mL) was irradiated in a microwave oven at 130° C. for 10 minutes. The mixture was diluted with dichloromethane and washed with a saturated aqueous solution of sodium bicarbonate. The organic layer was concentrated under reduced pressure and the crude material was purified by flash chromatography on silica gel (eluent 15 to 100% dichloromethane in heptane) to afford 1.21 g (84%) of methyl 3-benzylbenzoate.

1. customwas irradiated in a microwave oven at 130° C. for 10 minutes
2. washwashed with a saturated aqueous solution of sodium bicarbonate
3. concentrationThe organic layer was concentrated under reduced pressure
4. customthe crude material was purified by flash chromatography on silica gel (eluent 15 to 100% dichloromethane in heptane)