反应详情

A mixture of methyl 5-(3-fluorobenzyl)picolinate (0.149 g; 0.607 mmol) in NaOH 2M (2 mL) and ethanol (2 mL) was stirred at room temperature for 2 hours and then evaporated to dryness. The residue was dissolved in water and acidified to pH 2 with a 6N solution of hydrochloric acid in water. The mixture was extracted with ethyl acetate and the combined organic layers were dried and concentrated under reduced pressure. The crude material was used in the next step without any further purification.

1. customevaporated to dryness
2. dissolutionThe residue was dissolved in water
3. extractionThe mixture was extracted with ethyl acetate
4. customthe combined organic layers were dried
5. concentrationconcentrated under reduced pressure
6. customThe crude material was used in the next step without any further purification