Sodium Hydroxide → 4-(3-Fluorophenylamino)benzoic acid

Participants

Reaction Steps

Methyl 4-(3-fluorophenylamino)benzoate (0.110 g; 0.448 mmol) was added to a mixture of NaOH in water (1 mL; 2M) and dioxane (1 mL) and stirred vigorously at room temperature overnight. The resulting mixture was concentrated under reduced pressure and dissolved in water. The aqueous layer was acidified with a solution of hydrogen chloride 6M and the precipitated product was collected by filtration to yield 0.040 g (70%) of the title compound as a grey solid which was used without further purification.

Provenance & Evidence