Sodium Iodide → HCID 67974008, compound

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Reaction Steps

N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-4-(piperidin-1-ylmethyl)benzamide was prepared following Method C starting from N-(2-(5-chloro-1H-indol-3-yl)ethyl)-4-(chloromethyl)benzamide (0.070 g; 0.202 mmol), piperidine (0.090 mL; 0.907 mmol) and sodium iodide (0.153 g; 1.01 mmol) in THF (3 mL), microwave irradiation at 150° C. for 10 minutes. Flash chromatography on silica gel (eluent 3 to 20% ethanol in dichloromethane) furnished 0.072 g (90%) of the title compound as a white solid.

Provenance & Evidence