Piperazine → HCID 86699399, compound

Participants

Reaction Steps

N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-4-(piperazin-1-ylmethyl)benzamide was prepared following Method C starting from N-(2-(5-chloro-1H-indol-3-yl)ethyl)-4-(chloromethyl)benzamide (0.105 g; 0.302 mmol), piperazine (0.118 g; 1.36 mmol) and sodium iodide (0.229 g; 1.51 mmol) in THF (3 mL), under a microwave irradiation at 150° C. for 10 minutes. Flash chromatography on silica gel (eluent 2 to 16% methanol in dichloromethane) furnished 0.083 g (69%) of the title compound as a white solid.

Provenance & Evidence