Sodium Iodide → HCID 86699405, compound

Participants

Reaction Steps

N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-4-(3-methylbenzyl)benzamide was prepared according to method B with N-(2-(5-chloro-1H-indol-3-yl)ethyl)-4-(chloromethyl)benzamide (0.073 g; 0.209 mmol), m-tolylboronic acid (0.030 g; 0.220 mmol), tetrakis(triphenylphosphine)palladium(0) (0.012 g; 0.010 mmol), sodium carbonate (0.044 g; 0.419 mmol), sodium iodide (0.063 g; 0.419 mmol), in dimethoxyethane (3 mL) and water (1 mL), irradiated in a microwave oven at 130° C. for 15 minutes. Flash chromatography on silica gel (eluent 1 to 10% ethyl acetate in dichloromethane) furnished 0.040 g (46%) of the title compound as a white solid.

Provenance & Evidence