Sodium Iodide → HCID 86699433, compound

Participants

Reaction Steps

N-(2-(5-Chloro-1H-indol-3-yl)ethyl)-3-(furan-2-ylmethyl)benzamide was prepared according to method B with N-(2-(5-chloro-1H-indol-3-yl)ethyl)-3-(chloromethyl)benzamide (0.080 g; 0.230 mmol), furan-2-ylboronic acid (0.027 g; 0.241 mmol), tetrakis(triphenylphosphine)palladium (0.027 g; 0.023 mmol), sodium carbonate (0.049 g; 0.461 mmol), sodium iodide (0.069 g; 0.461 mmol), in dimethoxyethane (3 mL) and water (1 mL), irradiated in a microwave oven at 130° C. for 15 minutes. Flash chromatography on silica gel (eluent 20 to 100% ethyl acetate in heptane) furnished 0.028 g (32%) of the title compound as a white solid.

Provenance & Evidence