HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methoxytryptamine → HCID 67974597, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methoxytryptamine | HCID 1833 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67974126 | HCID 67974126 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67974597 | HCID 67974597 | 51.3% |
Reaction Steps
3-(3-Fluorobenzyl)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)benzamide was prepared according to method A with 2-(5-methoxy-1H-indol-3-yl)ethanamine (0.060 g; 0.315 mmol), 3-(3-fluorobenzyl)benzoic acid (0.073 g; 0.316 mmol), HATU (0.120 g; 0.316 mmol) and N,N-diisopropylethylamine (0.135 mL; 0.788 mmol) in DMF (5 mL). Flash chromatography on silica gel (eluent 1 to 20% ethyl acetate in dichloromethane) furnished 0.065 g (51%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266832B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-7dd83b53b07045e5a16f46a2a68f8904 |
| Source note | uspto-grants-2016_02 |