Water → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-fluoro-2-nitroaniline (1 g), 1-methylpiperazine (0.752 mL) and TEA (1.86 mL) in NMP (1.5 mL) was heated at 100° C. in a microwave oven for 20 h. After cooling down, H2O (50 mL) was added, the resulting suspension was stirred for 20 min and filtrated off. The yellow solid was washed with water and dried under high vacuo (1.45 g). LC-MS (B): tR=0.47 min; [M+H]+: 237.19.

Provenance & Evidence