HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → N-{4-[(Piperidin-1-yl)methyl]phenyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Acetamidobenzaldehyde | HCID 73942 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-{4-[(Piperidin-1-yl)methyl]phenyl}acetamide | HCID 348702 | — |
Reaction Steps
A mixture of 4-acetamidobenzaldehyde (200 mg), piperidine (0.121 mL), NaBH(OAc)3 (636 mg) and DIPEA (0.617 mL) in DCM (4 mL) was stirred at RT for 4 h. DCM and sat. NaHCO3 were added. The phases were separated, the org. layer was dried (Na2SO4), filtered off and evaporated to dryness to afford 267 mg of white solid. LC-MS (B): tR=0.45 min; [M+H]+: 233.24.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266876B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-578e7e78ee1c4990a038e179fb0342cd |
| Source note | uspto-grants-2016_02 |