Benzyl bromoacetate → HCID 89726362, compound

Participants

Reaction Steps

tert-Butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate (500 mg) was submitted to alkylation with benzyl bromoacetate, followed by cleavage of the Boc protecting group and subsequent methylation of the free amine using a method analogous to that of Precursor for Example 209 step 209.2 to step 209.4. However, the mixture of regioisomers was separated at the end of the three steps (Biotage, DCM/MeOH/TEA) to afford the two isomers:

Provenance & Evidence