(1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)acetic acid benzyl ester → (1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)-acetic acid

HRID 1777758Notes

Reaction equation

HRID 1777758 reaction equation
C([O:8][C:9](=[O:20])[CH2:10][N:11]1[CH2:16][CH2:15][C:14]2[NH:17][N:18]=[CH:19][C:13]=2[CH2:12]1)C1C=CC=CC=1>CCO>[NH:17]1[C:14]2[CH2:15][CH2:16][N:11]([CH2:10][C:9]([OH:20])=[O:8])[CH2:12][C:13]=2[CH:19]=[N:18]1

Participants

3

Reactant 1

HCID 89726571(1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)acetic acid benzyl ester

Product 1

HCID 89726036(1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)-acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The final compound was prepared using a method analogous to that of Example 14 step 14.2, (1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)acetic acid benzyl ester replacing intermediate 14.1 and using EtOH instead of MeOH/AcOH. LC-MS (B): tR=0.15 min; [M+H]+: 182.30.

Sources & evidence

ORD record
ord-49cf619ee71a44598079208f80f00a2b
Source dataset
uspto-grants-2016_02
Patent number
US09266876B2

Reaction notes

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