Morpholine → HCID 71571666, compound

Participants

Reaction Conditions

Reaction Steps

In a 5 mL microwave vial was placed 2-4 (221 mg, 0.599 mmol) and morpholine (2.0 g, 2.0 mL, 23 mmol). The mixture was heated at 120° C. under microwave irradiation for 20 min. After cooling, the reaction mixture was purified by reversed phase HPLC to give 191 mg (85%) of 6-1. 1H NMR (500 MHz, DMSO-d6): δ 8.51 (d, J=8.2 Hz, 1H), 8.05 (d, J=8.2 Hz, 1H), 7.96 (d, J=8.5 Hz, 1H), 7.83 (t, J=7.7 Hz, 1H), 7.69-7.60 (m, 2H), 7.00 (t, J=8.1 Hz, 1H), 6.67 (d, J=9.3 Hz, 1H), 5.72 (d, J=7.0 Hz, 1H), 4.32 (t, J=7.0 Hz, 2H), 3.63 (m, 4H), 3.10 (s, 1H), 2.99 (s, 1H), 2.93 (s, 4H). HRMS (ES) 376.1765 (M+H) found, 376.1771 required.

Provenance & Evidence