Morpholine → HCID 71571785, compound

Participants

Reaction Conditions

Reaction Steps

In a 1 mL microwave vial were placed 13-5 (22 mg, 0.064 mmol) and morpholine (1.00 g, 1.00 mL, 11.5 mmol). The vial was sealed and heated at 120° C. under microwave irradiation for 10 min. The reaction mixture was directly purified by reversed phase chromatography to give 14.0 mg (62%) of 13-6. 1H NMR δ (500 MHz, DMSO-d6): δ 8.44 (d, J=5.0 Hz, 1H), 7.81 (s, 1H), 7.36 (d, J=8.0 Hz, 1H), 7.28 (s, 1H), 7.01 (dd, J=9.3, 7.0 Hz, 1H), 6.72 (d, J=9.3 Hz, 1H), 5.75 (d, J=7.0 Hz, 1H), 3.90 (dd, J=6.9, 3.9 Hz, 2H), 3.74 (t, J=4.6 Hz, 4H), 3.12-3.03 (m, 4H), 2.25 (dt, J=8.5, 4.6 Hz, 1H), 1.84 (s, 1H), 1.23-1.15 (m, 2H). HRMS (ES) 352.1761 (M+H) found, 352.1768 required.

Provenance & Evidence