Methyl 4-(aminomethyl)benzoate → Tert-butyl(S)-7-isopropyl-3-((4-(methoxycarbonyl)benzyl)carbamoyl)-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Methyl 4-(aminomethyl)benzoate	HCID 571728	—
Reactant	tert-butyl (S)-3-((4-(ethylsulfonyl)benzyl)carbamoyl)-7-isopropyl-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate	HCID 118274902	—
Product	Tert-butyl(S)-7-isopropyl-3-((4-(methoxycarbonyl)benzyl)carbamoyl)-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate	HCID 118274873	—

Reaction Steps

Procedure same as that for tert-butyl(S)-3-((4-(ethylsulfonyl)benzyl)carbamoyl)-7-isopropyl-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate, using methyl4-(aminomethyl)benzoate as a starting material. LC-MS tR=1.61 min in 2 min chromatography, MS (ESI) m/z 454.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09266886B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-43202e0b86ca4892b5bc9e0aee1bde2a
Source note	uspto-grants-2016_02