Tert-butyl(S)-7-isopropyl-3-((4-(methoxycarbonyl)benzyl)carbamoyl)-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate → Methyl (S)-4-((7-isopropyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamido)methyl)benzoate
Reaction equation
C([C@H]1C2=NC=C(C(OC)=O)C=C2CN1)(C)C.[CH:17]([C@H:20]1[C:24]2=[N:25][CH:26]=[C:27]([C:29](=[O:42])[NH:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([C:38]([O:40][CH3:41])=[O:39])=[CH:34][CH:33]=3)[CH:28]=[C:23]2[CH2:22][N:21]1C(OC(C)(C)C)=O)([CH3:19])[CH3:18]>>[CH:17]([C@H:20]1[C:24]2=[N:25][CH:26]=[C:27]([C:29]([NH:30][CH2:31][C:32]3[CH:33]=[CH:34][C:35]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:37]=3)=[O:42])[CH:28]=[C:23]2[CH2:22][NH:21]1)([CH3:19])[CH3:18]Participants
3
Reactant 2
Product 1
Procedure
Procedure same as that for methyl(S)-7-isopropyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate, using tert-butyl(S)-7-isopropyl-3-((4-(methoxycarbonyl)benzyl)carbamoyl)-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate as a starting material. LC-MS tR=0.73 min in 2 min chromatography, MS (ESI) m/z 354.
Sources & evidence
- ORD record
- ord-07d0052f2e864f49a79f6de530f7e0b2
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09266886B2
Reaction notes
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