Methyl (S)-4-((7-isopropyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamido)methyl)benzoate → Methyl (S)-4-((7-isopropyl-6-(4-(trifluoromethyl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamido)methyl)benzoate
Reaction equation
C(S([C:6]1[CH:38]=[CH:37][C:9]([CH2:10][NH:11][C:12]([C:14]2[CH:15]=[C:16]3[CH2:22][N:21]([CH2:23][C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)[C@@H:20]([CH:34]([CH3:36])[CH3:35])[C:17]3=[N:18][CH:19]=2)=[O:13])=[CH:8][CH:7]=1)(=O)=O)C.C([C@H]1C2=NC=C(C(NCC3C=CC([C:59]([O:61][CH3:62])=[O:60])=CC=3)=O)C=C2CN1)(C)C>>[CH:34]([C@H:20]1[C:17]2=[N:18][CH:19]=[C:14]([C:12]([NH:11][CH2:10][C:9]3[CH:8]=[CH:7][C:6]([C:59]([O:61][CH3:62])=[O:60])=[CH:38][CH:37]=3)=[O:13])[CH:15]=[C:16]2[CH2:22][N:21]1[CH2:23][C:24]1[CH:25]=[CH:26][C:27]([C:30]([F:33])([F:31])[F:32])=[CH:28][CH:29]=1)([CH3:36])[CH3:35]Participants
3
Reactant 2
Product 1
Procedure
Procedure same as that for (S)-N-(4-(ethylsulfonyl)benzyl)-7-isopropyl-6-(4-(trifluoromethyl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide, using methyl(S)-4-((7-isopropyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamido)methyl)benzoate as a starting material. LC-MS tR=1.34 min in 2 min chromatography, MS (ESI) m/z 512 [M+H]+.
Sources & evidence
- ORD record
- ord-24683789c7574f52b3521a05d86b6be2
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09266886B2
Reaction notes
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