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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777848Generated: October 31, 2026

5-Aminopyrazine-2-carbonitrile → N-(5-cyanopyrazin-2-yl)-7-(dimethoxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

https://huagongshe.com/reaction/1777848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Aminopyrazine-2-carbonitrileHCID 13925294—
Reactantphenyl 7-(dimethoxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylateHCID 118037161—
ProductN-(5-cyanopyrazin-2-yl)-7-(dimethoxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamideHCID 118036535—

Reaction Steps

From intermediate 3 and 5-aminopyrazine-2-carbonitrile, reacted in an analogous manner to the preparation of intermediate 2. (UPLC-MS 1) tR 1.08 min, ESI-MS 355.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-265ef4a36a9a4c5aa5a308d173d1ba97
Source noteuspto-grants-2016_02