4-Amino-6-methoxypyrimidine → 7-(dimethoxymethyl)-N-(6-methoxypyrimidin-4-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

HRID 1777854Notes

Reaction equation

[CH3:1][O:2][CH:3]([O:23][CH3:24])[C:4]1[N:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][N:11]2[C:14]([O:16]C2C=CC=CC=2)=O)=[CH:6][CH:5]=1.[CH3:25][O:26][C:27]1[N:32]=[CH:31][N:30]=[C:29]([NH2:33])[CH:28]=1>>[CH3:24][O:23][CH:3]([O:2][CH3:1])[C:4]1[N:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][N:11]2[C:14]([NH:33][C:29]2[CH:28]=[C:27]([O:26][CH3:25])[N:32]=[CH:31][N:30]=2)=[O:16])=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 7357314-Amino-6-methoxypyrimidine

HCID 118037161HCID 118037161, compound

Product 1

HCID 1180366597-(dimethoxymethyl)-N-(6-methoxypyrimidin-4-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

Procedure

From intermediate 3 and 6-methoxypyrimidin-4-amine, reacted in an analogous manner to the preparation of intermediate 6. (UPLC-MS 1) tR 1.06 min; ESI-MS 360.2 [M+H]+.

Sources & evidence

ORD record: ord-472d8fe327ae47359012273d996e04e4
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09266883B2

Reaction notes

Loading…