Ammonia → 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine

Participants

Reaction Conditions

Reaction Steps

In a sealed tube, a mixture of 2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine (100 mg, 0.289 mmol) and ammonia (2 M in 2-propanol, 1.44 ml, 2.89 mmol) in 2-propanol (1.5 ml) was stirred at 80° C. for 2 days, then ammonia (2 M in 2-propanol, 1.44 ml, 2.89 mmol) was added and the reaction mixture was stirred at 80° C. for 7 days. The reaction mixture was cooled to room temperature and evaporated; the crude mixture was then diluted with EtOAc and washed with water; the organic phase was then dried over Na2SO4, filtered and evaporated to give the title compound as a yellow resin. (UPLC-MS 1) tR 0.83 min; ESI-MS 327.0 [M+H]+.

Provenance & Evidence