Tetrahydrofurfuryl alcohol → (Racemic) 6-amino-4-((tetrahydrofuran-2-yl)methoxy)nicotinonitrile

Participants

Reaction Conditions

Reaction Steps

6-amino-4-chloronicotinonitrile (intermediate 16, 70 mg, 0.456 mmol) and (tetrahydrofuran-2-yl)methanol (233 mg, 2.28 mmol) were charged into a vial. DMA (1 ml) was added to the mixture at room temperature followed by NaH (60% in mineral oil dispersion, 109 mg, 2.73 mmol). The mixture was then heated at 70° C. for 16 h. The reaction mixture was cooled to room temperature, diluted in EtOAc and washed with aq. pH7 buffer (2×) and brine. The organic layer was dried over

Provenance & Evidence