Tetrahydropyran-2-methanol → HCID 118036282, compound

HRID 1777881Notes

Reaction equation

HRID 1777881 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](Cl)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[O:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[CH2:17][OH:18]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:18][CH2:17][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][O:11]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 7524Tetrahydropyran-2-methanolHCID 219492196-Amino-4-chloro-3-pyridinecarbonitrile

Product 1

HCID 118036282HCID 118036282, compound

Procedure

From intermediate 16 and (tetrahydro-2H-pyran-2-yl)methanol, reacted in an analogous manner to the preparation of intermediate 34. (UPLC-MS 3) tR 0.69 min; ESI-MS 234.1 [M+H]+.

Sources & evidence

ORD record
ord-0276eac3b4024ba780fdac94056e842d
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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