HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-fluoropyridine → 6-(((tert-butyldimethylsilyl)oxy)methyl)-7-(dimethoxymethyl)-N-(5-fluoropyridin-2-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-fluoropyridine | HCID 2737701 | — |
| Reactant | phenyl 6-(((tert-butyldimethylsilyl)oxy)methyl)-7-(dimethoxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate | HCID 131734775 | — |
| Product | 6-(((tert-butyldimethylsilyl)oxy)methyl)-7-(dimethoxymethyl)-N-(5-fluoropyridin-2-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide | HCID 131734776 | — |
Reaction Steps
From intermediate 38 and 5-fluoropyridin-2-amine, reacted in an analogous manner to the preparation of intermediate 37. (UPLC-MS 3) tR 1.64 min; ESI-MS 491.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266883B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-3a979f12099d4224bd2a4a08b7aa43f1 |
| Source note | uspto-grants-2016_02 |