HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777889Generated: October 31, 2026
4-Methylpiperidin-4-ol → 3-Pyridinecarbonitrile, 6-amino-4-(4-hydroxy-4-methyl-1-piperidinyl)-
https://huagongshe.com/reaction/1777889
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylpiperidin-4-ol | HCID 15649174 | — |
| Reactant | 6-Amino-4-chloro-3-pyridinecarbonitrile | HCID 21949219 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 3-Pyridinecarbonitrile, 6-amino-4-(4-hydroxy-4-methyl-1-piperidinyl)- | HCID 118036903 | — |
Reaction Steps
A suspension of 6-amino-4-chloronicotinonitrile (intermediate 16, 31.6 mg, 0.206 mmol) and 4-hydroxy-4-methylpiperidine (47.4 mg, 0.412 mmol) in DMA (0.75 ml) was heated to 100° C. and stirred for 1 h. The resulting brown solution was heated to 120° C. and stirred for 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09266883B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-b1a95c67082545368851d8f70bbc6743 |
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| Source note | uspto-grants-2016_02 |
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