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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777898Generated: November 1, 2026

(S)-(+)-3-Hydroxytetrahydrofuran → (S)-6-amino-4-((tetrahydrofuran-3-yl)oxy)nicotinonitrile

https://huagongshe.com/reaction/1777898

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-(+)-3-HydroxytetrahydrofuranHCID 2733227—
Reactant6-Amino-4-fluoronicotinonitrileHCID 118036901—
Product(S)-6-amino-4-((tetrahydrofuran-3-yl)oxy)nicotinonitrileHCID 118036650—

Reaction Steps

From intermediate 21 and (S)-tetrahydrofuran-3-ol, reacted in an analogous manner to the preparation of intermediate 47. (UPLC-MS 3) tR 0.48 min; ESI-MS 206.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-13dfce3f58db4c9bb59329d79f36a568
Source noteuspto-grants-2016_02